Propylparaben; propyl 4-hydroxybenzoate

CAS Number
Propylparaben; propyl 4-hydroxybenzoate
SIN Groups
Reason for inclusion on the SIN List
Propylparaben is an endocrine disruptor with estrogenic and antiandrogen activity, affecting sperm function and prenatal development among others. The substance has been detected in biomonitoring studies and human urine and milk. It is categorized as an endorine disruptor in the EU Commision Database.
Date for inclusion on the SIN List
2011 May
REACH status, appears on
Source: ECHA
CoRAP list
Registration information
Source: ECHA
Full registration
Hazard class and category code(s)
Source: ECHA
No harmonized CLP classification

Chemical information

Propylparaben; n-propyl-p-hydroxybenzoate; Propyl-4-hydroxybenzoate; E216
EC number
Registered production volume
Source: ECHA
100 - 1000 tonnes per annum
(Bio)monitoring data
Yes, it has been found in rivers, and in effluents from sewage treatment plants.

Possible uses
Source: DHI 2006; 
Cosmetics, food, rubber, pharmaceuticals, plastics
Technical function of substances
Source: DHI 2006;,%20ETHYL,%20PROPYL,%20BUTYL%29.htm
Preservative, polymerization activators and retardants, anti-microbial, anti-fermentation additives and tabletting lubricant for pharmaceuticals. Corrosion inhibitor, additive in antifreeze coolants in waterborne systems, as a nucleating agents for polyolefin, as a dye intermediate, as a stabilizer in photographic processing, catalyst. 
Registered use(s) - Chemical Product category (PC)
Source: ECHA
PC 28: Perfumes, fragrances
PC 29: Pharmaceuticals
PC 39: Cosmetics, personal care products
Registered use(s) - Environmental Release Category (ERC)
Source: ECHA
ERC 2: Formulation of preparations
ERC 8a: Wide dispersive indoor use of processing aids in open systems
Registered use(s) - Process Category (PROC)
Source: ECHA
PROC 14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation
PROC 15: Use as laboratory reagent
PROC 1: Use in closed process, no likelihood of exposure
PROC 2: Use in closed, continuous  process with occasional controlled exposure
PROC 3: Use in closed batch process (synthesis or formulation)
PROC 4: Use in batch and other process (synthesis) where opportunity for exposure arises
PROC 5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/or significant contact)
PROC 8a: Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at non-dedicated facilities
PROC 8b: Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities
PROC 9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing)


Company Group
Company Name

AVANTOR PERFORMANCE MATERIALS PARIS KY PLANT, 7001 Martin Luther King Jr Blvd, Paris, Bourbon, 40361, KY, US, , USA


Clariant Produkte (Deutschland) GmbH, Am Unisys-Park 1 65843 Sulzbach am Taunus Germany , , Germany

Clariant Produkte (Deutschland) GmbH , Am Unisys-Park 1 65843 Sulzbach am Taunus Germany, , Germany

ELC Group

ELC Group s.r.o., Karolinská 650/1 186-00 Prague 8 Czech Republic , , Czech Republic


knoell Germany - OR - E9, Konrad-Zuse-Ring 25 68163 Mannheim Germany , , Germany

Nexeo Solutions

NEXEO SOLUTIONS LLC, 5200 Blazer Pkwy Ds-3, Dublin, Franklin, 43017, OH, US, , USA

SCAS Group Laboratories

SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium , , Belgium

SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium , , Belgium

SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 MC-SQUARE Offices B-1831 Diegem Belgium , , Belgium

Source: ECHA