Butylated Hydroxytoluene

CAS Number
128-37-0
Name
Butylated Hydroxytoluene
SIN Groups
Alkylphenols
Reason for inclusion on the SIN List
This substance has endocrine disrupting properties. In vivo studies of Butylated Hydroxytoluene has shown that the substance disrupts thyroid gland function and morphology. Reduced fertility, altered growth and development, impaired learning and motor behaviours have also been observed in vivo. In vitro studies further indicate interference with testis enzymes, steroid production, growth hormones and antiandrogenic acitivity.
Date for inclusion on the SIN List
2014 October
REACH status, appears on
Source: ECHA
CoRAP list
Registration information
Source: ECHA
Full registration
Hazard class and category code(s)
Source: ECHA
No harmonized CLP classification

Chemical information

Synonyms
2,6-di-tert-butyl-4-methylphenol; 2,6-di-tert-butyl-p-cresol
EC number
204-881-4
Registered production volume
Source: ECHA
10000 - 100000 tonnes per annum
(Bio)monitoring data
BHT was detected in agricultural irrigation water in Spain.  In an Italian study BHT was detected in all samples of conventional milk and in 10 % of organic milk samples. It was also detected in Japanese mineral water in glass bottles, but not in plastic bottles. It was suggested that the compound derived from the bottle cap. (Higuchi et al., 2004; Pattono et al., 2009; Calderón-Preciado et al., 2011)
Possible uses
Source: 
This substance has endocrine disrupting properties. In vivo studies of Butylated Hydroxytoluene has shown that the substance disrupts thyroid gland function and morphology. Reduced fertility, altered growth and development, impaired learning and motor behaviours have also been observed in vivo. In vitro studies further indicate interference with testis enzymes, steroid production, growth hormones and antiandrogenic acitivity.
Technical function of substances
Source: 
Antioxidant for petroleum products, jet fuels, food products, food packaging and animal feeds. Stabilizer in motor and aviation gasoline. Source: HSDB
Registered use(s) - Sector End Use (SU)
Source: ECHA
SU 10: Formulation [mixing] of preparations and/or re-packaging (excluding alloys)
SU 11: Manufacture of rubber products
SU 12: Manufacture of plastics products, including compounding and conversion
SU 17: General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment
SU 18: Manufacture of furniture
SU 19: Building and construction work
SU 24: Scientific research and development
SU 5: Manufacture of textiles, leather, fur
SU 6a: Manufacture of wood and wood products
SU 6b: Manufacture of pulp, paper and paper products
SU 7: Printing and reproduction of recorded media
SU 8: Manufacture of  bulk, large scale chemicals (including petroleum products)
Registered use(s) - Chemical Product category (PC)
Source: ECHA
PC 12: Fertilisers
PC 13: Fuels
PC 14: Metal surface treatment products, including galvanic and electroplating products
PC 15: Non-metal-surface treatment products
PC 16: Heat transfer fluids
PC 17: Hydraulic fluids
PC 18: Ink and toners
PC 1: Adhesives, sealants
PC 21: Laboratory chemicals
PC 23: Leather tanning, dye, finishing, impregnation and care products
PC 24: Lubricants, greases, release products
PC 25: Metal working fluids
PC 27: Plant protection products
PC 28: Perfumes, fragrances
PC 29: Pharmaceuticals
PC 31: Polishes and wax blends
PC 32: Polymer preparations and compounds
PC 34: Textile dyes, finishing and impregnating products
including bleaches and other processing aids
PC 35: Washing and cleaning products (including solvent based products)
PC 39: Cosmetics, personal care products
PC 3: Air care products
PC 4: Anti-freeze and de-icing products
PC 8: Biocidal products (e.g. disinfectants, pest control)
PC 9a: Coatings and paints, thinners, paint removes
PC 9b: Fillers, putties, plasters, modelling clay
PC 9c: Finger paints
Registered use(s) - Article category (AC)
Source: 
AC 10: Rubber articles
AC 11: Wood articles
AC 13: Plastic articles
AC 1: Vehicles
AC 2: Machinery, mechanical appliances, electrical/electronic articles
AC 4: Stone, plaster, cement, glass and ceramic articles
AC 5: Fabrics, textiles and apparel
AC 6: Leather articles
AC 7: Metal articles
AC 8: Paper articles
Registered use(s) - Environmental Release Category (ERC)
Source: ECHA
ERC  7: Industrial use of substances in closed systems
ERC 10a: Wide dispersive outdoor use of long-life articles and materials with low release
ERC 10b: Wide dispersive outdoor use of long-life articles and materials with high or intended release (including abrasive processing)
ERC 11a: Wide dispersive indoor use of long-life articles and materials with low release
ERC 11b: Wide dispersive indoor use of long-life articles and materials with high or intended release (including abrasive processing)
ERC 12a: Industrial processing of articles with abrasive techniques (low release)
ERC 12b: Industrial processing of articles with abrasive techniques (high release)
ERC 1: Manufacture of substances
ERC 2: Formulation of preparations
ERC 3: Formulation in materials
ERC 4: Industrial use of processing aids in processes and products, not becoming part of articles
ERC 5: Industrial use resulting in inclusion into or onto a matrix
ERC 6b: Industrial use of reactive processing aids
ERC 6d: Industrial use of  process regulators for polymerisation processes in  production of resins, rubbers, polymers
ERC 8a: Wide dispersive indoor use of processing aids in open systems
ERC 8c: Wide dispersive indoor use resulting in inclusion into or onto a matrix
ERC 8d: Wide dispersive outdoor use of processing aids in open systems
ERC 8f: Wide dispersive outdoor use resulting in inclusion into or onto a matrix
ERC 9a: Wide dispersive indoor use of substances in closed systems
ERC 9b: Wide dispersive outdoor use of substances in closed systems
Registered use(s) - Process Category (PROC)
Source: ECHA
PROC 10: Roller application or brushing
PROC 11: Non industrial spraying
PROC 13: Treatment of articles by dipping and pouring
PROC 14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation
PROC 15: Use as laboratory reagent
PROC 16: Using material as fuel sources, limited exposure to unburned product to be expected
PROC 17: Lubrication at high energy conditions and in partly open process
PROC 18: Greasing at high energy conditions
PROC 19: Hand-mixing with intimate contact and only PPE available.
PROC 1: Use in closed process, no likelihood of exposure
PROC 20: Heat and pressure transfer fluids in dispersive, professional use but closed systems
PROC 21: Low energy manipulation of substances bound in materials and/or articles
PROC 23: Open processing and transfer operations with minerals/metals at elevated temperature
PROC 24: High (mechanical) energy work-up of substances bound in materials and/or articles
PROC 2: Use in closed, continuous  process with occasional controlled exposure
PROC 3: Use in closed batch process (synthesis or formulation)
PROC 4: Use in batch and other process (synthesis) where opportunity for exposure arises
PROC 5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/or significant contact)
PROC 6: Calendering operations
PROC 7: Industrial spraying
PROC 8a: Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at non-dedicated facilities
PROC 8b: Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities
PROC 9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing)
128-37-0

Producers

Company Group
Company Name
3M

3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem, , Belgium

Addivant

Addivant France SAS, 4 Chemin du Trou Bieuet,60840, Catenoy 62, France

Brenntag

BRENNTAG GREAT LAKES, LLC - WAUWATOSA WAREHOUSE, 4420 N Harley Davidson Ave, Wauwatosa, Milwaukee, 53226, WI, , USA

CHARKIT CHEMICAL

Charkit Chemical Corporation, 32 Haviland Street, Norwalk, Fairfield, 06854, CT, , USA

DIC Group

Sun Chemical B.V., Leeuwenveldseweg 3-t, 1382 LV, Weesp, Netherlands

Emery Oleochemicals

EMERY OLEOCHEMICALS, 4900 Este Avenue, Cincinnati, Hamilton, 45232, OH, , USA

ExxonMobil

EXXONMOBIL CHEMICAL COMPANY, 22777 Springwoods Village Pkwy, Spring, Harris, 77389, TX, , USA

ExxonMobil Petroleum & Chemical BVBA OR01, Polderdijkweg,2030, Antwerpen, Belgium

Huber Group

MHM Holding GmbH, Feldkirchener Straße 15, D-85551, Kirchheim, Germany

Idemitsu Kosan

IDEMITSU LUBRICANTS AMERICA, 701 Port Road, Jeffersonville, Clark, 47130-8425, IN, , USA

JSR TRADING

JSR TRADING, INC., 5300 Dupont Circle, Milford, Clermont, 45150, OH, , USA

KRATON POLYMERS

KRATON POLYMERS US LLC CORPORATE OFFICE, 15710 John F Kennedy Blvd, Houston, Harris, 77032, TX, , USA

Lanxess

LANXESS CORP, 111 Ridc Park West Dr, Pittsburgh, Allegheny County, 15275-1112, PA, , USA

Lanxess Deutschland GmbH, Kennedyplatz 1,50569, Köln Nordrhein-Westfalen, Germany

NEVILLE CHEMICAL CO

NEVILLE CHEMICAL CO, 2800 Neville Road, Pittsburgh, Allegheny, 15225-1496, PA, , USA

NewMarket Corporation

Afton Chemical Ltd, London Road, RG12 2UW, Bracknell Berkshire, United Kingdom

Oxiris

Oxiris Chemicals S.A., Ctra C-35 Km59 Pol Ind Nord-est,8470, Sant Celoni, Spain

PMC Group

PMC SPECIALTIES GROUP INC, 501 Murray Road, Cincinnati, Hamilton, 45217-1014, OH, , USA

QUANEX BUILDING PRODUCTS

QUANEX IG SYSTEMS, 800 Cochran Avenue, Cambridge, Guernsey, 43725-9336, OH, , USA

RESINALL CORPORATION

RESINALL CORPORATION, 302 Water Street, Severn, Northampton, 27877, NC, , USA

RESINALL MISSISSIPPI INC, 102 Dixie Pine Rd., Hattiesburg, Forrest, 39401, MS, , USA

Sasol

SASOL CHEMICALS (USA) LLC, 292 State Route 8, Oil City, Venango, 16301, PA, , USA

Sasol UK Limited, 1 Hockley Court, 2401 Stratford Road, B94 6NW, Solihull, United Kingdom

S-LEC

SEKISUI S-LEC AMERICA, LLC, 1200 Rolling Hills Ln, Winchester, Clark, 40391, KY, , USA

TEXTILE RUBBER & CHEMICAL

Tiarco Chemical (Division of Textile Rub, 1350 Tiarco Drive Sw, Dalton, Whitfield, 30721, GA, , USA

WILBUR-ELLIS HOLDINGS

CONNELL BROS. CO. LLC, 345 California St, San Francisco, San Francisco, 94104, CA, , USA

Zeon Chemicals

ZEON CHEMICALS L.P.- RESEARCH & DEVELOPMENT LABORATORY, 4111 Bells Lane, Louisville, Jefferson, 40211-2126, KY, , USA

ZEON CHEMICALS TEXAS PLANT, 11235 Choate Road, Pasadena, Harris, 77507-1727, TX, , USA

Source: ECHA