CAS Number
128-37-0
Name
Butylated Hydroxytoluene
SIN Groups
Alkylphenols
Reason for inclusion on the SIN List
This substance has endocrine disrupting properties. In vivo studies of Butylated Hydroxytoluene has shown that the substance disrupts thyroid gland function and morphology. Reduced fertility, altered growth and development, impaired learning and motor behaviours have also been observed in vivo. In vitro studies further indicate interference with testis enzymes, steroid production, growth hormones and antiandrogenic acitivity. Date for inclusion on the SIN List
2014 October
REACH status, appears on
Source: ECHA CoRAP list
Registration information
Source: ECHA
Full registration
Hazard class and category code(s)
Source: ECHA No harmonized CLP classification ![]() ![]() ![]() Chemical informationSynonyms
2,6-di-tert-butyl-4-methylphenol; 2,6-di-tert-butyl-p-cresol
EC number
204-881-4
Registered production volume
Source: ECHA 10000 - 100000 tonnes per annum
(Bio)monitoring data
BHT was detected in agricultural irrigation water in Spain. In an Italian study BHT was detected in all samples of conventional milk and in 10 % of organic milk samples. It was also detected in Japanese mineral water in glass bottles, but not in plastic bottles. It was suggested that the compound derived from the bottle cap. (Higuchi et al., 2004; Pattono et al., 2009; Calderón-Preciado et al., 2011)
Possible uses
Source:
This substance has endocrine disrupting properties. In vivo studies of Butylated Hydroxytoluene has shown that the substance disrupts thyroid gland function and morphology. Reduced fertility, altered growth and development, impaired learning and motor behaviours have also been observed in vivo. In vitro studies further indicate interference with testis enzymes, steroid production, growth hormones and antiandrogenic acitivity.
Technical function of substances
Source: Antioxidant for petroleum products, jet fuels, food products, food packaging and animal feeds. Stabilizer in motor and aviation gasoline. Source: HSDB
Registered use(s) - Sector End Use (SU)
Source: ECHA SU 10: Formulation [mixing] of preparations and/or re-packaging (excluding alloys) SU 11: Manufacture of rubber products SU 12: Manufacture of plastics products, including compounding and conversion SU 17: General manufacturing, e.g. machinery, equipment, vehicles, other transport equipment SU 18: Manufacture of furniture SU 19: Building and construction work SU 24: Scientific research and development SU 5: Manufacture of textiles, leather, fur SU 6a: Manufacture of wood and wood products SU 6b: Manufacture of pulp, paper and paper products SU 7: Printing and reproduction of recorded media SU 8: Manufacture of bulk, large scale chemicals (including petroleum products)
Registered use(s) - Chemical Product category (PC)
Source: ECHA PC 12: Fertilisers PC 13: Fuels PC 14: Metal surface treatment products, including galvanic and electroplating products PC 15: Non-metal-surface treatment products PC 16: Heat transfer fluids PC 17: Hydraulic fluids PC 18: Ink and toners PC 1: Adhesives, sealants PC 21: Laboratory chemicals PC 23: Leather tanning, dye, finishing, impregnation and care products PC 24: Lubricants, greases, release products PC 25: Metal working fluids PC 27: Plant protection products PC 28: Perfumes, fragrances PC 29: Pharmaceuticals PC 31: Polishes and wax blends PC 32: Polymer preparations and compounds PC 34: Textile dyes, finishing and impregnating products including bleaches and other processing aids PC 35: Washing and cleaning products (including solvent based products) PC 39: Cosmetics, personal care products PC 3: Air care products PC 4: Anti-freeze and de-icing products PC 8: Biocidal products (e.g. disinfectants, pest control) PC 9a: Coatings and paints, thinners, paint removes PC 9b: Fillers, putties, plasters, modelling clay PC 9c: Finger paints
Registered use(s) - Article category (AC)
Source: AC 10: Rubber articles AC 11: Wood articles AC 13: Plastic articles AC 1: Vehicles AC 2: Machinery, mechanical appliances, electrical/electronic articles AC 4: Stone, plaster, cement, glass and ceramic articles AC 5: Fabrics, textiles and apparel AC 6: Leather articles AC 7: Metal articles AC 8: Paper articles
Registered use(s) - Environmental Release Category (ERC)
Source: ECHA ERC 7: Industrial use of substances in closed systems ERC 10a: Wide dispersive outdoor use of long-life articles and materials with low release ERC 10b: Wide dispersive outdoor use of long-life articles and materials with high or intended release (including abrasive processing) ERC 11a: Wide dispersive indoor use of long-life articles and materials with low release ERC 11b: Wide dispersive indoor use of long-life articles and materials with high or intended release (including abrasive processing) ERC 12a: Industrial processing of articles with abrasive techniques (low release) ERC 12b: Industrial processing of articles with abrasive techniques (high release) ERC 1: Manufacture of substances ERC 2: Formulation of preparations ERC 3: Formulation in materials ERC 4: Industrial use of processing aids in processes and products, not becoming part of articles ERC 5: Industrial use resulting in inclusion into or onto a matrix ERC 6b: Industrial use of reactive processing aids ERC 6d: Industrial use of process regulators for polymerisation processes in production of resins, rubbers, polymers ERC 8a: Wide dispersive indoor use of processing aids in open systems ERC 8c: Wide dispersive indoor use resulting in inclusion into or onto a matrix ERC 8d: Wide dispersive outdoor use of processing aids in open systems ERC 8f: Wide dispersive outdoor use resulting in inclusion into or onto a matrix ERC 9a: Wide dispersive indoor use of substances in closed systems ERC 9b: Wide dispersive outdoor use of substances in closed systems
Registered use(s) - Process Category (PROC)
Source: ECHA PROC 10: Roller application or brushing PROC 11: Non industrial spraying PROC 13: Treatment of articles by dipping and pouring PROC 14: Production of preparations or articles by tabletting, compression, extrusion, pelletisation PROC 15: Use as laboratory reagent PROC 16: Using material as fuel sources, limited exposure to unburned product to be expected PROC 17: Lubrication at high energy conditions and in partly open process PROC 18: Greasing at high energy conditions PROC 19: Hand-mixing with intimate contact and only PPE available. PROC 1: Use in closed process, no likelihood of exposure PROC 20: Heat and pressure transfer fluids in dispersive, professional use but closed systems PROC 21: Low energy manipulation of substances bound in materials and/or articles PROC 23: Open processing and transfer operations with minerals/metals at elevated temperature PROC 24: High (mechanical) energy work-up of substances bound in materials and/or articles PROC 2: Use in closed, continuous process with occasional controlled exposure PROC 3: Use in closed batch process (synthesis or formulation) PROC 4: Use in batch and other process (synthesis) where opportunity for exposure arises PROC 5: Mixing or blending in batch processes for formulation of preparations and articles (multistage and/or significant contact) PROC 6: Calendering operations PROC 7: Industrial spraying PROC 8a: Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at non-dedicated facilities PROC 8b: Transfer of substance or preparation (charging/discharging) from/to vessels/large containers at dedicated facilities PROC 9: Transfer of substance or preparation into small containers (dedicated filling line, including weighing) ProducersCompany Group
Company Name
3M
3M Belgium BVBA/SPRL, Hermeslaan 7 1831 Diegem Belgium , , Belgium
3M Belgium BVBA/SPRL , Hermeslaan 7 1831 Diegem Belgium, , Belgium Afton Chemical
Afton Chemical S.P.R.L. (Woluwe), Alma Court Lenneke Marelaan, 8 B-1932 St-Stevens-Woluwe Belgium , , Belgium
BASF
BASF SE, Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany , , Germany
BASF SE , Carl-Bosch-Str. 38 67056 Ludwigshafen am Rhein Rheinland-Pfalz Germany, , Germany Brenntag
BRENNTAG GREAT LAKES, LLC - WAUWATOSA WAREHOUSE, 4420 N Harley Davidson Ave, Wauwatosa, Milwaukee, 53226, WI, US, , USA
CHARKIT CHEMICAL
Charkit Chemical Corporation, 32 Haviland Street, Norwalk, Fairfield, 06854, CT, US, , USA
Charkit Chemical Corporation, 32 Haviland Street, Norwalk, US, , USA Chemijos Industrija
CHEMIJOS INDUSTRIJA UAB, Birutes str. 16a LT-91210 Klaipėda Lithuania , , Lithuania
CHEMIJOS INDUSTRIJA UAB, Turgaus str. 2-4 LT-91246 Klaipėda Lithuania , , Lithuania Chevron
Chevron Oronite SA - OR - CVX Oronite Cy LLC, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France , , France
Chevron Oronite SA M/I, Le Corosa 1, rue Eugène et Armand Peugeot CS10022 92508 Rueil-Malmaison Cedex France , , France DIC Group
Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands , , Netherlands
Sun Chemical B.V., Leeuwenveldseweg 3-t 1382 LV Weesp Netherlands, , Netherlands DOW
DOW BENELUX B.V. OR-3, Postbus 48 4530 AA Terneuzen Netherlands , , Netherlands
DuPont de Nemours
Specialty Electronic Materials Netherlands B.V. OR-1, Herbert H. Dowweg 5 4542NM Hoek Netherlands , , Netherlands
Envigo
Envigo Consulting Limited, Woolley Road PE28 4HS Huntingdon United Kingdom , , United Kingdom
Envigo Consulting Limited, Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom , , United Kingdom Envigo Consulting Limited, Woolley Road Alconbury PE28 4HS Huntingdon Cambridgeshire United Kingdom , , United Kingdom Envigo Research Limited 105, Shardlow Business Park London Road DE72 2GD Shardlow Derbyshire United Kingdom , , United Kingdom ExxonMobil
EXXONMOBIL CHEMICAL COMPANY, 22777 Springwoods Village Pkwy, Spring, Harris, 77389, TX, US, , USA
EXXONMOBIL CHEMICAL COMPANY, 22777 Springwoods Village Pkwy, Spring, US, , USA ExxonMobil Petroleum & Chemical, BVBA, Polderdijkweg 2030 Antwerpen Belgium , , Belgium Givaudan
GIVAUDAN FRAGRANCES CORPORATION, International Trade Center, Mount Olive, Morris, 07828-1384, NJ, US, , USA
Henkel
Henkel Global Supply Chain B.V., Gustav Mahlerlaan 2970 1081 LA Amsterdam Netherlands , , Netherlands
Huber Group
MHM Holding GmbH, Feldkirchener Straße 15 D-85551 Kirchheim Germany , , Germany
Idemitsu Kosan
IDEMITSU LUBRICANTS AMERICA, 701 Port Road, Jeffersonville, Clark, 47130-8425, IN, US, , USA
JSR TRADING
JSR TRADING, INC., 5300 Dupont Circle, Milford, Clermont, 45150, OH, US, , USA
KRATON POLYMERS
KRATON POLYMERS US LLC CORPORATE OFFICE, 15710 John F Kennedy Blvd, Houston, Harris, 77032, TX, US, , USA
Lanxess
LANXESS CORP, 111 Ridc Park West Dr, Pittsburgh, Allegheny County, 15275-1112, PA, US, , USA
LANXESS CORP, 111 Ridc Park West Dr, Pittsburgh, US, , USA Lanxess Deutschland GmbH, Kennedyplatz 1 50569 Köln Germany , , Germany Lanxess Deutschland GmbH , Kennedyplatz 1 50569 Köln Germany, , Germany LANXESS SOLUTIONS UK LTD (US01), Tenax Road M17 1WT Manchester United Kingdom , , United Kingdom NEVILLE CHEMICAL CO
NEVILLE CHEMICAL CO, 2800 Neville Road, Pittsburgh, Allegheny, 15225-1496, PA, US, , USA
Oxiris
Oxiris Chemicals S.A., Ctra C-35 Km59 Pol Ind Nord-est 08470 Sant Celoni Spain , , Spain
PMC Group
PMC SPECIALTIES GROUP INC, 501 Murray Road, Cincinnati, Hamilton, 45217-1014, OH, US, , USA
PTT Global Chemical Public Company Limited
EMERY OLEOCHEMICALS, 4900 Este Avenue, Cincinnati, Hamilton, 45232, OH, US, , USA
QUANEX BUILDING PRODUCTS
QUANEX IG SYSTEMS, 800 Cochran Avenue, Cambridge, Guernsey, 43725-9336, OH, US, , USA
RESINALL CORPORATION
RESINALL CORPORATION, 302 Water Street, Severn, Northampton, 27877, NC, US, , USA
RESINALL MISSISSIPPI INC, 102 Dixie Pine Rd., Hattiesburg, Forrest, 39401, MS, US, , USA Rotam
Rotam Europe Limited, Hamilton House Mabledon Place WC1H 9BB London United Kingdom , , United Kingdom
Sasol
SASOL CHEMICALS (USA) LLC, 12120 Wickchester Lane, Houston, Harris, 77079, TX, US, , USA
SASOL CHEMICALS (USA) LLC, 2201 Old Spanish Trail, Westlake, Calcasieu, 70669, LA, US, , USA SASOL CHEMICALS (USA) LLC, 292 State Route 8, Oil City, Venango, 16301, PA, US, , USA SCAS Group Laboratories
SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium , , Belgium
SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 B-1831 Diegem Belgium , , Belgium SCAS Europe S.A./N.V., Leonardo Da Vincilaan 19 MC-SQUARE Offices B-1831 Diegem Belgium , , Belgium Service Provider
Chemservice S.A. (4T8L), 5, an de Laengten 6776 Grevenmacher Luxembourg , , Luxembourg
HH Compliance Ltd., Block D Unit 14 Nutgrove Office Park, Rathfarnham 14 Dublin Ireland , , Ireland HH Compliance Ltd., Rubicon Building, CIT Campus Bishopstown Cork Cork Ireland , , Ireland HH Compliance Ltd., Rubicon Building, CIT Campus Bishopstown none Cork Ireland , , Ireland HH Compliance Ltd., Rubicon Building, CIT-Campus Bishopstown 0000 Cork Ireland , , Ireland HH Compliance Ltd., Rubicon Building, CIT-Campus Bishopstown none Cork Ireland , , Ireland HH Compliance Ltd., Rubicon-Building, CIT-Campus Bishopstown none Cork Ireland , , Ireland HH Compliance Ltd., Rubicon-Building, CIT-Campus Bishopstown none Cork Cork Ireland , , Ireland HH Compliance Ltd., The Rubicon Building, CIT Campus Bishopstown N/A Cork Ireland , , Ireland HH Compliance Ltd., The Rubicon Centre, CIT Campus Bishopstown T12 Y275 Cork Cork Ireland , , Ireland HH Compliance Ltd., The Rubicon Centre, CIT Campus, 0000 Bishopstown, Cork Ireland , , Ireland HH Compliance Ltd. , Rubicon Building, CIT Campus Bishopstown none Cork Ireland, , Ireland SI Group
Addivant Germany GmbH, Teplitzer Strasse 14-16 84478 Waldkraiburg Germany , , Germany
Sigma-Aldrich
SIGMA-ALDRICH CHEMIE GMBH, Riedstrasse 2 89555 Steinheim Germany , , Germany
SIGMA-ALDRICH CHEMIE GMBH , Riedstrasse 2 89555 Steinheim Germany, , Germany Sinopec Group
CHEMICAL INSPECTION & REGULATION SERVICE LIMITED(Sinopec Lubricant Co.,Ltd.), Room 002, Regus Harcourt Centre D02 HW77 D02 Dublin Ireland , , Ireland
S-LEC
SEKISUI S-LEC AMERICA, LLC, 1200 Rolling Hills Ln, Winchester, Clark, 40391, KY, US, , USA
TEXTILE RUBBER & CHEMICAL
Tiarco Chemical (Division of Textile Rub, 1350 Tiarco Drive Sw, Dalton, US, , USA
Tiarco Chemical (Division of Textile Rub, 1350 Tiarco Drive Sw, Dalton, Whitfield, 30721, GA, US, , USA WILBUR-ELLIS HOLDINGS
CONNELL BROS. CO. LLC, 345 California St, San Francisco, San Francisco, 94104, CA, US, , USA
Zeon Chemicals
ZEON CHEMICALS L.P.- RESEARCH & DEVELOPMENT LABORATORY, 4111 Bells Lane, Louisville, Jefferson, 40211-2126, KY, US, , USA
ZEON CHEMICALS TEXAS PLANT, 11235 Choate Road, Pasadena, Harris, 77507-1727, TX, US, , USA Source: ECHA |